Vardenafil, also known as Levitra is a perscription medicine that is used to treat erectile dysfunction in men. It is part of a major drug group called called PDE5 inhibitors. Levitra expands blood stream to the penis, which picks up and helps keeping an erection during sex. Levitra’s dynamic fixing chips away at the chain of responses inside the penis amid excitement, when the process of filling the cavernous bodies of the penis takes place, bringing about an erection.
During a penile erection, the penis is filled with blood which causes the erection. This happens as a result of the growth and expansion of the veins that deliver blood to the penile structures, while the blood vessels responsible for removing blood from the penis do the opposite (contract), bringing about a gathering of blood in the penis
At the point when a male is sexually stimulated, nitric oxide is discharged into his penis. A cascade of responses is triggered by this substance – it makes a compound, guanylate cyclase deliver cyclic guanosine monophosphate (cGMP). cGMP manages the constriction and widening (enlargement) of veins deliver blood to the penis or remove blood from it. This reactions brings about the dilation of the blood vessels responsible for penis blood supply, while contracting the ones that empty the penis from blood, bringing about an erection.
An enzyme called Phosphodiesterase-5 (PDE5) breaks down cGMP. As a result of cGMP breakdown blood vessels return to their typical size, thus ending the erection. Vardenafil prolongs CGMP’s function by inhibiting PDE5’s action towards cGMP. Simply speaking it helps maintain an erection for longer. Levitra is accessible in different doses: you can find them in 2.5 or 5 or 10, and 20 mg pills which have round shape and orange color. Most patients begin on 10 mg, which is roughly identical a sildenafil (Viagra) dose equivalent to 50 mg. Patients ought to take Levitra around 1-2 hours before a sexual act, and shall only one tabllet at regular intervals. In different countries of the world, including the UK only 5, 10 and 20 mg doses are sold. Essential data states that Levitra can bring about a genuine and risky drop in blood circulatory (hypotension) on the off chance that it is consumed along with some other professionally prescribed meds. Dizziness and fainting may be some of the adverse effects one can experience. There is an additional danger of stroke and heart attack.
Individuals who are on medication called “nitrates” or recreational drugs such as poppers (amyl nitrate and/or butyl nitrate) ought not to take Levitra.
History of Levitra (vardenafil)
Vardenafil started out as a co-promoting arrangement between Bayer, GSK and Schering Plough pharmaceutical companies and was then named Levitra. Co-promotion right were afterwards returned to Bayer by GSK in many regions outside USA. Levitra (Bayer) and Vivanza are the two brand names given by the only two companies that sell Vardenafil in Italy.
The European Comission has granted approval for a new formulation of Levitra (vardenafil HCI). The first ED (erectile dysfunction) medicine to be available as a result of this great and convenient formulation is orodispersible 10mg Levitra pills. Tongue solubility with a light minty flavor as a convenient, discreet and attractive intake method is what makes the orodispersible 10mg Levitra pills much better than other medicaments of the same group. This product will enter the European market at November 2010. The US already approved this medication at June 2010 and it will enter the market under the name STAXYN by GlaxoSmithKline and Merck & Co., Inc.
“Being committed to solving men’s health problems Bayer Schering Pharma continuously struggles to bring innovation to erectile dysfunction treatment options that are available,” stated Dr. Flemming Oernskov who is the Head of the Business Unit Women’s Healthcare and General Medicine at Bayer Schering Pharma in Berlin. “We believe that individuals who suffer from ED will much appreciate a convenient and easy way to receive these medications, as part of our efforts. Orodispersible Levitra pills give men the opportunity to get ready without being troubled finding the right time and place. This will help make the sex life of men who suffer from ED rather spontaneous.”
Various clinical trials (1-10) have proven Vardenafil to be safe and efficient. So to prove this, Levitra orodispersible 10mg pills were examined with the help of Phase III multinational trials Potent I and II (Pivotal III trial as to study and compare with placebo the safety and efficiency of orodispersible Vardenafil pills in patients suffering from erectile dysfunction: fix-dose, double blind and randomized multicenter trials were included in the process of study). The safety and efficiency of orodispersible 10mg Vardenafil pills was compared with placebo after a 12-week treatment course on a wide range of men with ED. These two worldwide twin reviews were directed with indistinguishable review configuration, selecting a sum of 882 men over the age of 18 years who had ED for over 6 months. (11,12), For both POTENT I and POTENT II ponders, vardenafil orodispersible treatment was factually essentially better than fake treatment for all essential (IIEF-EF, SEP2, SEP3) and optional adequacy measures (all p<0.0001).
About Erectile Dysfunction
Erectile dysfunction (ED) is a state where a man cannot (always or partially) acquire or maintain an erection sufficient enough to have a sexual intercourse. An expected 152 million men around the world, 16 percent of all men matured 20-75 around the world (13), encounter erection challenges. It is anticipated that the overall predominance of ED will increment to 322 million by 2025 (14). In spite of its wide commonness, late information recommends that numerous men with ED don’t look for treatment. Additionally, ED can be the first symptom of a cardiovascular disease and ought to in this way be considered important by patients and doctors (15). More instruction and data on the doctors and patient side is expected to change this.